2- 5 Although their availability differs among European countries, topical 5% permethrin together with oral ivermectin is one of the most widely prescribed first-line scabicidal therapy. 1 Current guidelines propose a range of different treatment regimens taking into account topical permethrin, benzyl benzoate, sulfur, malathion, crotamiton, synergized pyrethrins and topical or oral ivermectin as the only systemic therapeutic option. Scabies is a rising major public health issue worldwide and has recently been designated as a neglected tropical disease by the World Health Organization (WHO). Human scabies is usually transmitted during skin-to-skin contact with persons infested with the ectoparasitic mite Sarcoptes scabiei var. A combination of both agents may be considered in recalcitrant and extensively infested cases, additionally to crusted scabies. Therefore, both agents constitute an adequate first-line therapy in the treatment of scabies. Topical BB and oral ivermectin have shown comparable good therapeutic efficacy. Tolerability and safety profile of oral ivermectin was excellent, while BB produced short burning sensations in 14%. In group B, successful retreatment was observed in three out of three patients with ivermectin, two of two patients with BB and 11 of 11 patients with the combination of BB plus ivermectin, respectively. After initial therapy failure in group A, six out of eight patients showed treatment response upon repeated application of BB, five of five when retreated with ivermectin and two of two with BB plus ivermectin, respectively. Treatment resulted in a cure rate of 87% in group A and 86% in group B. Treatment outcome was evaluated by dermoscopy at a 3-week follow-up visit. Group A received topical 25% or 10% BB for the daily use over a period of three consecutive days, group B received oral ivermectin (200 μg/kg body weight) twice, 1 week apart. In total, 224 patients were enrolled and sequentially randomized into two equally sized groups. Patients with dermoscopy-verified scabies visiting the dermatologic outpatient clinic were assessed for enrolment in the study. To evaluate the comparative efficacy, safety and tolerability of topical benzyl benzoate (BB) with oral ivermectin in the treatment of scabies. Recent reports indicate there is a decreasing efficacy of the standard treatment of choice, topical 5% permethrin cream. Scabies is an itchy, parasitic infection of the skin.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |